Saturday 23rd October 2021
| Aldwinians | vs | Liverpool St Helens | 14:15 |
| Didsbury Toc H | vs | Eccles | 14:15 |
| West Park St Helens | vs | Liverpool Collegiate | 14:15 |
| Widnes | vs | Ormskirk | 14:15 |
| Wigan | vs | Oldham | 14:15 |
| Withdrawn - Burnley | a | a | Fleetwood | ||
| a | |||||
Saturday 6th November 2021
| Fleetwood | vs | Didsbury Toc H | 14:15 |
| Liverpool Collegiate | vs | Eccles | 14:15 |
| Liverpool St Helens | h | h | Withdrawn - Burnley | ||
| h | |||||
| Oldham | vs | Aldwinians | 14:15 |
| Ormskirk | vs | Wigan | 14:15 |
| West Park St Helens | vs | Widnes | 14:15 |
Saturday 13th November 2021
| Liverpool St Helens | vs | Wigan | 14:15 |
Saturday 20th November 2021
| Liverpool Collegiate | vs | Fleetwood | 14:15 |
| Liverpool St Helens | vs | Eccles | 14:15 |
| Oldham | vs | Didsbury Toc H | 14:15 |
| Ormskirk | h | h | Withdrawn - Burnley | ||
| h | |||||
| West Park St Helens | vs | Aldwinians | 14:15 |
| Widnes | vs | Wigan | 14:15 |
Saturday 4th December 2021
| Aldwinians | vs | Widnes | 14:15 |
| Didsbury Toc H | vs | Ormskirk | 14:15 |
| Eccles | vs | Oldham | 14:15 |
| Fleetwood | vs | Liverpool St Helens | 14:15 |
| Liverpool Collegiate | vs | Wigan | 14:15 |
| Withdrawn - Burnley | a | a | West Park St Helens | ||
| a | |||||
Saturday 11th December 2021
| Aldwinians | vs | Ormskirk | 14:15 |
| Didsbury Toc H | vs | Liverpool St Helens | 14:15 |
| Eccles | vs | Fleetwood | 14:15 |
| Widnes | vs | Liverpool Collegiate | 14:15 |
| Wigan | vs | West Park St Helens | 14:15 |
| Withdrawn - Burnley | a | a | Oldham | ||
| a | |||||
Saturday 18th December 2021
| Aldwinians | vs | Liverpool Collegiate | 14:15 |
| Oldham | vs | Liverpool St Helens | 14:15 |
| Ormskirk | vs | Fleetwood | 14:15 |
| West Park St Helens | vs | Eccles | 14:15 |
| Widnes | vs | Didsbury Toc H | 14:15 |
| Wigan | h | h | Withdrawn - Burnley | ||
| h | |||||
Saturday 8th January 2022
| Didsbury Toc H | vs | Wigan | 14:15 |
| Eccles | vs | Widnes | 14:15 |
| Fleetwood | vs | West Park St Helens | 14:15 |
| Liverpool Collegiate | vs | Oldham | 14:15 |
| Liverpool St Helens | vs | Ormskirk | 14:15 |
| Withdrawn - Burnley | a | a | Aldwinians | ||
| a | |||||
Saturday 15th January 2022
| Aldwinians | vs | Didsbury Toc H | 14:15 |
| Ormskirk | vs | Oldham | 14:15 |
| West Park St Helens | vs | Liverpool St Helens | 14:15 |
| Widnes | vs | Fleetwood | 14:15 |
| Wigan | vs | Eccles | 14:15 |
| Withdrawn - Burnley | a | a | Liverpool Collegiate | ||
| a | |||||
Saturday 22nd January 2022
| Didsbury Toc H | h | h | Withdrawn - Burnley | ||
| h | |||||
| Eccles | vs | Aldwinians | 14:15 |
| Fleetwood | vs | Wigan | 14:15 |
| Liverpool Collegiate | vs | Ormskirk | 14:15 |
| Liverpool St Helens | vs | Widnes | 14:15 |
| Oldham | vs | West Park St Helens | 14:15 |
Saturday 29th January 2022
| Aldwinians | vs | Fleetwood | 14:15 |
| Didsbury Toc H | vs | Liverpool Collegiate | 14:15 |
| West Park St Helens | vs | Ormskirk | 14:15 |
| Widnes | vs | Oldham | 14:15 |
| Wigan | vs | Liverpool St Helens | 14:15 |
| Withdrawn - Burnley | h | h | Eccles | ||
| h | |||||
Saturday 12th February 2022
| Eccles | vs | Didsbury Toc H | 14:15 |
| Fleetwood | h | h | Withdrawn - Burnley | ||
| h | |||||
| Liverpool Collegiate | vs | West Park St Helens | 14:15 |
| Liverpool St Helens | vs | Aldwinians | 14:15 |
| Oldham | vs | Wigan | 14:15 |
| Ormskirk | vs | Widnes | 14:15 |
Saturday 19th February 2022
| Aldwinians | vs | Oldham | 14:15 |
| Didsbury Toc H | vs | Fleetwood | 14:15 |
| Eccles | vs | Liverpool Collegiate | 14:15 |
| Widnes | vs | West Park St Helens | 14:15 |
| Wigan | vs | Ormskirk | 14:15 |
| Withdrawn - Burnley | a | a | Liverpool St Helens | ||
| a | |||||
Saturday 5th March 2022
| Fleetwood | vs | Eccles | 14:15 |
| Liverpool Collegiate | vs | Widnes | 14:15 |
| Liverpool St Helens | vs | Didsbury Toc H | 14:15 |
| Oldham | h | h | Withdrawn - Burnley | ||
| h | |||||
| Ormskirk | vs | Aldwinians | 14:15 |
| West Park St Helens | vs | Wigan | 14:15 |
Saturday 19th March 2022
| Aldwinians | vs | West Park St Helens | 14:15 |
| Didsbury Toc H | vs | Oldham | 14:15 |
| Eccles | vs | Liverpool St Helens | 14:15 |
| Fleetwood | vs | Liverpool Collegiate | 14:15 |
| Wigan | vs | Widnes | 14:15 |
| Withdrawn - Burnley | a | a | Ormskirk | ||
| a | |||||
Saturday 2nd April 2022
| Liverpool St Helens | vs | Fleetwood | 14:15 |
| Oldham | vs | Eccles | 14:15 |
| Ormskirk | vs | Didsbury Toc H | 14:15 |
| West Park St Helens | h | h | Withdrawn - Burnley | ||
| h | |||||
| Widnes | vs | Aldwinians | 14:15 |
| Wigan | vs | Liverpool Collegiate | 14:15 |
Saturday 9th April 2022
| Didsbury Toc H | vs | West Park St Helens | 14:15 |
| Eccles | vs | Ormskirk | 14:15 |
| Fleetwood | vs | Oldham | 14:15 |
| Liverpool St Helens | vs | Liverpool Collegiate | 14:15 |
| Wigan | vs | Aldwinians | 14:15 |
| Withdrawn - Burnley | a | a | Widnes | ||
| a | |||||