Saturday 30th April 2022
| Widnes 2 | 10 | 20 | Aldwinians 2 |
Saturday 23rd April 2022
| Liverpool Collegiate 2 | 47 | 0 | Wigan 2 |
Saturday 16th April 2022
| Aldwinians 2 | 47 | 7 | Trafford MV 2 |
Saturday 9th April 2022
| Littleborough 2 | 7 | 40 | Aldwinians 2 |
| Liverpool St Helens 2 | 52 | 15 | Liverpool Collegiate 2 |
| Sefton 2 | h | h | Wigan 2 | ||
| h | |||||
| West Park St Helens 2 | h | h | Trafford MV 2 | ||
| h | |||||
Saturday 2nd April 2022
| Aldwinians 2 | 40 | 14 | Sefton 2 |
| Trafford MV 2 | a | a | Liverpool St Helens 2 | ||
| a | |||||
| Widnes 2 | 41 | 19 | Liverpool Collegiate 2 |
| Wigan 2 | a | a | West Park St Helens 2 | ||
| a | |||||
Sunday 27th March 2022
| Liverpool Collegiate 2 | 67 | 3 | Trafford MV 2 |
| Liverpool St Helens 2 | 22 | 31 | Sefton 2 |
| West Park St Helens 2 | 19 | 61 | Littleborough 2 |
| Wigan 2 | 28 | 35 | Aldwinians 2 |
Saturday 19th March 2022
| Liverpool St Helens 2 | h | h | Wigan 2 | ||
| h | |||||
| Sefton 2 | 29 | 57 | Littleborough 2 |
| West Park St Helens 2 | 43 | 34 | Aldwinians 2 |
| Widnes 2 | 27 | 0 | Trafford MV 2 |
Saturday 12th March 2022
| Liverpool Collegiate 2 | 38 | 17 | West Park St Helens 2 |
Saturday 5th March 2022
| Aldwinians 2 | h | h | Liverpool St Helens 2 | ||
| h | |||||
| Littleborough 2 | h | h | Liverpool Collegiate 2 | ||
| h | |||||
| Sefton 2 | 42 | 7 | West Park St Helens 2 |
| Wigan 2 | a | a | Widnes 2 | ||
| a | |||||
Saturday 19th February 2022
| Liverpool Collegiate 2 | a | a | Trafford MV 2 | ||
| a | |||||
| Liverpool St Helens 2 | P | P | Sefton 2 |
| West Park St Helens 2 | P | P | Littleborough 2 |
| Widnes 2 | P | P | Aldwinians 2 |
Saturday 12th February 2022
| Littleborough 2 | 52 | 0 | Trafford MV 2 |
| Sefton 2 | 5 | 66 | Widnes 2 |
| West Park St Helens 2 | 29 | 10 | Liverpool St Helens 2 |
Saturday 29th January 2022
| Liverpool Collegiate 2 | 25 | 19 | Aldwinians 2 |
| Liverpool St Helens 2 | 33 | 46 | Littleborough 2 |
| Trafford MV 2 | 23 | 24 | Wigan 2 |
| Widnes 2 | 46 | 5 | West Park St Helens 2 |
Saturday 15th January 2022
| Aldwinians 2 | P | P | Trafford MV 2 |
| Littleborough 2 | 59 | 7 | Wigan 2 |
| Liverpool St Helens 2 | 22 | 22 | Widnes 2 |
| West Park St Helens 2 | P | P | Oldham 2 - WITHDRAWN |
Saturday 8th January 2022
| Liverpool Collegiate 2 | P | P | West Park St Helens 2 |
| Oldham 2 - WITHDRAWN | P | P | Liverpool St Helens 2 |
| Widnes 2 | h | h | Littleborough 2 | ||
| h | |||||
| Wigan 2 | P | P | Aldwinians 2 |
Saturday 18th December 2021
| Liverpool Collegiate 2 | a | a | Widnes 2 | ||
| a | |||||
| Liverpool St Helens 2 | P | P | Trafford MV 2 |
| Oldham 2 - WITHDRAWN | P | P | Littleborough 2 |
| Sefton 2 | 15 | 23 | Aldwinians 2 |
| West Park St Helens 2 | 35 | 15 | Wigan 2 |
Saturday 11th December 2021
| Aldwinians 2 | P | P | West Park St Helens 2 |
| Littleborough 2 | 52 | 3 | Sefton 2 |
| Liverpool Collegiate 2 | P | P | Oldham 2 - WITHDRAWN |
| Trafford MV 2 | 0 | 78 | Widnes 2 |
| Wigan 2 | 15 | 13 | Liverpool St Helens 2 |
Saturday 4th December 2021
| Liverpool Collegiate 2 | 0 | 5 | Littleborough 2 |
| Liverpool St Helens 2 | 0 | 27 | Aldwinians 2 |
| Oldham 2 - WITHDRAWN | P | P | Trafford MV 2 |
| West Park St Helens 2 | 38 | 15 | Sefton 2 |
| Widnes 2 | 16 | 12 | Wigan 2 |
Saturday 27th November 2021
| Trafford MV 2 | 56 | 15 | Liverpool Collegiate 2 |
| Wigan 2 | 66 | 19 | Littleborough 2 |
Saturday 20th November 2021
| Aldwinians 2 | 29 | 0 | Widnes 2 |
| Littleborough 2 | 22 | 19 | West Park St Helens 2 |
| Sefton 2 | 19 | 32 | Liverpool St Helens 2 |
| Wigan 2 | P | P | Oldham 2 - WITHDRAWN |
Saturday 13th November 2021
| Liverpool Collegiate 2 | 33 | 27 | Wigan 2 |
Saturday 6th November 2021
| Liverpool St Helens 2 | 41 | 0 | West Park St Helens 2 |
| Oldham 2 - WITHDRAWN | P | P | Aldwinians 2 |
| Trafford MV 2 | 28 | 39 | Littleborough 2 |
| Widnes 2 | 40 | 0 | Sefton 2 |
Saturday 23rd October 2021
| Widnes 2 | 59 | 13 | Liverpool St Helens 2 |
Saturday 16th October 2021
| Aldwinians 2 | 31 | 7 | Liverpool Collegiate 2 |
| Littleborough 2 | 22 | 21 | Liverpool St Helens 2 |
| Sefton 2 | P | P | Oldham 2 - WITHDRAWN |
| West Park St Helens 2 | 7 | 26 | Widnes 2 |
| Wigan 2 | 49 | 12 | Trafford MV 2 |
Saturday 9th October 2021
| Wigan 2 | 52 | 7 | Sefton 2 |
Saturday 2nd October 2021
| Liverpool Collegiate 2 | 38 | 14 | Sefton 2 |
| Oldham 2 - WITHDRAWN | P | P | West Park St Helens 2 |
| Trafford MV 2 | 21 | 59 | Aldwinians 2 |
Saturday 18th September 2021
| Aldwinians 2 | 22 | 19 | Wigan 2 |
| Littleborough 2 | 17 | 56 | Widnes 2 |
| Liverpool St Helens 2 | P | P | Oldham 2 - WITHDRAWN |
| Sefton 2 | 14 | 43 | Trafford MV 2 |
| West Park St Helens 2 | 41 | 17 | Liverpool Collegiate 2 |
Saturday 11th September 2021
| Aldwinians 2 | 26 | 19 | Littleborough 2 |
| Liverpool Collegiate 2 | 19 | 21 | Liverpool St Helens 2 |
| Oldham 2 - WITHDRAWN | P | P | Widnes 2 |
| Trafford MV 2 | 48 | 29 | West Park St Helens 2 |