Saturday 27th February 2021
| Birchfield | vs | Liverpool Medics | 14:15 |
| Broughton | vs | Ashton under Lyne | 14:15 |
| Didsbury Old Bedians | vs | Clitheroe | 14:15 |
| Dukinfield | vs | Bury | 14:15 |
| Marple | vs | Ruskin Park | 14:15 |
| North Manchester | vs | Colne & Nelson | 14:15 |
Saturday 13th March 2021
| Ashton under Lyne | vs | Marple | 14:15 |
| Bury | vs | Broughton | 14:15 |
| Clitheroe | vs | Dukinfield | 14:15 |
| Colne & Nelson | vs | Didsbury Old Bedians | 14:15 |
| Liverpool Medics | vs | North Manchester | 14:15 |
| Ruskin Park | vs | Birchfield | 14:15 |
Saturday 20th March 2021
| Birchfield | vs | Ashton under Lyne | 14:15 |
| Broughton | vs | Clitheroe | 14:15 |
| Didsbury Old Bedians | vs | North Manchester | 14:15 |
| Dukinfield | vs | Colne & Nelson | 14:15 |
| Marple | vs | Bury | 14:15 |
| Ruskin Park | vs | Liverpool Medics | 14:15 |
Saturday 27th March 2021
| Ashton under Lyne | vs | Ruskin Park | 14:15 |
| Bury | vs | Birchfield | 14:15 |
| Clitheroe | vs | Marple | 14:15 |
| Colne & Nelson | vs | Broughton | 14:15 |
| Liverpool Medics | vs | Didsbury Old Bedians | 14:15 |
| North Manchester | vs | Dukinfield | 14:15 |
Saturday 17th April 2021
| Birchfield | vs | Clitheroe | 14:15 |
| Broughton | vs | North Manchester | 14:15 |
| Dukinfield | vs | Didsbury Old Bedians | 14:15 |
| Liverpool Medics | vs | Ashton under Lyne | 14:15 |
| Marple | vs | Colne & Nelson | 14:15 |
| Ruskin Park | vs | Bury | 14:15 |